منابع مشابه
Reduced growth rate of dimethylhydrazine-induced colon tumors in rats.
alpha-Difluoromethylornithine (DFMO) treatment has been shown to modify carcinogenesis in many experimental tumor models, including breast, urinary bladder, and colon. This study was designed to determine whether DFMO treatment can inhibit tumor growth on chemical-induced colon cancer in rats. Effectiveness of DFMO in combination with mitomycin C (MMC) was also evaluated. Forty-two Sprague-Dawl...
متن کاملComparison of chlortenoxicam and indomethacin on frusemide-induced diuresis.
A single oral dose of chlortenoxicam 4 mg, a new non-steroidal anti-inflammatory drug, significantly antagonized the diuretic and natriuretic actions of frusemide when compared with placebo in normal human volunteers. Indomethacin 50 mg significantly reduced the natriuretic, but not diuretic action of frusemide.
متن کاملThe dimethylhydrazine induced colorectal tumours in rat - experimental colorectal carcinogenesis
The beginnings of the first animal model appreciated for its macroscopic and histological similarity to human colorectal carcinoma (CRC) extend to 1963, when Laqueur discovered that rats fed cycasin, a plant product, developed intestinal cancer. The active substance was identified and soon a similar compound, methylazoxymethanol acetate (MAMA) was synthesized that was more effective than the na...
متن کاملComparison of flupirtine and indomethacin on frusemide-induced diuresis.
A single oral dose of flupirtine maleate, a novel analgesic agent, did not antagonize significantly the diuretic action of frusemide when compared with indomethacin and placebo in normal human volunteers.
متن کاملEffect of osmotic and mercurial diuresis on simultaneous water diuresis.
A VARIETY of mechanisms have been proposed to explain the dilute urine excreted in water diuresis. Cushny (I) and Smith (2) may be consulted for references to the older literature. Theoretical concepts which have been current in recent years will be considered in more detail in the discussion at the end of this paper. The experiments reported here were devised to test the degree to which water ...
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ژورنال
عنوان ژورنال: Toxicology and Applied Pharmacology
سال: 1967
ISSN: 0041-008X
DOI: 10.1016/0041-008x(67)90024-5